![]() ![]() acetylcysteine for the treatment of NAI-ALF and severe alcoholic hepatitis and in the prevention of CIN are inconclusive, though some evidence supports its use in certain populations. ![]() The benefit for this indication is limited to surrogate markers such as serum creatinine and in patients with multiple risk factors for the development of CIN.ĭata regarding the use of i.v. acetylcysteine provides antioxidants and vasodilation. When used for the prevention of CIN, i.v. A trial of 174 patients with severe alcoholic hepatitis revealed that patients had 28-day survival benefit when treated with acetylcysteine improvement in patients with hepatorenal syndrome was also noted. acetylcysteine serves as an antioxidant and glutathione source. When used to treat severe alcoholic hepatitis, i.v. One large randomized trial of 173 adults with NAI-ALF from any etiology and of any grade encephalopathy demonstrated overall improvement in transplant-free survival, particularly for patients with low-grade encephalopathy, though overall survival was not improved. acetylcysteine is used in the treatment of NAI-ALF to improve oxygenation to the liver. and oral formulations of acetylcysteine have been evaluated for these indications, most studies have examined the i.v. Generic name: acetylcysteine (oral) a-SEET-il-SIS-teen Brand names: NAC, N-A-C Sustain Dosage forms: oral capsule (500 mg 600 mg), oral tablet (600 mg) Drug classes: Antidotes, Mucolytics Medically reviewed by on Dec 26, 2022. acetylcysteine is most often used as an antidote for acetaminophen overdose due to its ability to increase levels of glutathione however, it is also used to treat NAI-ALF and severe alcoholic hepatitis and to prevent CIN. The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed.
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